Sinus mast cell accumulation and persistence suggest a unique endotype in toxin exposure-associated chronic rhinosinusitis.

Wang, Xinyu; Huang, Yung-An; Sethi, Anshika; Yue, Christopher; Brack, Sydney; Chattuparambil Binoy, Aiswarya; Crowther, Lauren; Yan, Carol et al. · J Clin Invest · 2026

basic_science · Level V

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Abstract

This study identifies a toxin-associated chronic rhinosinusitis endotype, defined by persistent mast cell accumulation, advancing understanding of how environmental exposures may drive chronic airway disease.

Medical subject headings