Point-of-Care Urine Tenofovir Drug-Level Feedback Counseling Improves Long-term PrEP Adherence for U.S. MSM in Pilot RCT.

Spinelli, Matthew A; Ewart, Leah Davis; Ross, Emily J; Heise, Megan J; Buccheri, Renata; Moreira, Carlos; Mahuvakar, Shivani; Glidden, David V et al. · Clin Infect Dis · 2026

rct · Level II

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Abstract

A remote, motivational interviewing-informed intervention using self-administered point-of-care urine tenofovir testing improved long-term pre-exposure prophylaxis (PrEP) adherence among young U.S. men-who-have-sex-with-men in a pilot randomized trial. Participants increased hair tenofovir levels by one to two tablets weekly, with high feasibility and acceptability, supporting further implementation.