Serotonin modulates nucleus accumbens circuits to suppress aggression in mice.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 41690929.
- Also identified by DOI 10.1038/s41467-026-69254-x and PMC identifier 13018284.
- Licence recorded as CC BY-NC-ND.
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Abstract
Serotonin (5-hydroxytryptamine; 5HT) has long been considered anti-aggressive, but the mechanisms by which 5HT regulates downstream circuits to control aggression remain unclear. Combining fiber photometry, optogenetics, and miniaturized microscope recordings in double-transgenic male mice, we find that 5HT levels ramp up in the nucleus accumbens during aggression, inhibiting a subset of D1 medium spiny neurons to suppress attacks. Our results reveal a novel 5HT-mediated neuromodulatory mechanism for limiting aggressive behavior.
Medical subject headings
- Nucleus Accumbens
- Serotonin
- Aggression