Association Between C-Reactive Protein-Triglyceride-Glucose Index and Outcomes After Endovascular Thrombectomy in Patients with Acute Ischemic Stroke.

Abstract

This study aimed to examine the relationship between the C-reactive protein-triglyceride-glucose index (CTI) and clinical outcomes in patients with acute stroke caused by large vessel occlusion in the anterior circulation following endovascular thrombectomy (EVT). This retrospective study included patients who underwent EVT between January 1, 2020, and December 31, 2023. The CTI was computed using the following formula: 0.412 × Ln (C-reactive protein [mg/L]) + Ln (triglyceride [mg/dL] × fasting plasma glucose [mg/dL])/2. Based on the optimal cutoff value determined through receiver operating characteristic curve analysis, patients were categorized into low-CTI and high-CTI groups. The primary functional outcome was a favorable functional status at 90 days, defined as a modified Rankin Scale of 0-2. The relationship between CTI and clinical outcomes after EVT was assessed using univariate and multivariate logistic regression analyses. Data from 366 patients with acute stroke were analyzed. The univariate analysis revealed that higher CTI levels were associated with unfavorable functional outcomes. The multivariate-adjusted model demonstrated a significant association between CTI levels and clinical functional outcomes (95% confidence interval: 0.29-0.78; P = 0.004). The receiver operating characteristic curve analysis confirmed the ability of CTI to predict poor functional outcomes, with an area under the curve of 0.60. CTI shows a significant relationship with clinical functional outcomes in patients with acute anterior circulation large vessel occlusion ischemic stroke following EVT.