Enhancing IgG fragment crystallizable sialylation improves the therapeutic activity of IL-23 cytokine blockade.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 41712290.
- Also identified by DOI 10.1172/jci.insight.198630.
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Abstract
The manuscript demonstrates that the activity of cytokine blocking antibodies can be enhanced by introducing a highly sialylated IgG Fc-domain.
Medical subject headings
- Immunoglobulin G
- Interleukin-23
- Immunoglobulin Fc Fragments
- N-Acetylneuraminic Acid