Test Performance of Expired Malaria Rapid Diagnostic Tests: A pilot diagnostic accuracy study conducted in Western Uganda.
cross_sectional · Level IV
Where this comes from
- Record sourced from PubMed, PMID 41712406.
- Also identified by DOI 10.1093/infdis/jiag105.
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Abstract
We evaluated the diagnostic agreement of expired malaria rapid diagnostic tests (mRDTs) with non-expired mRDTs in a clinical setting in western Uganda. Expired mRDTs (SD Bioline Ag Pf/Pan and First Reponse Ag pLDH/HRP2) were administered to each participant in parallel with a non-expired mRDT serving as the reference. Of 200 participants, 21 (10.5%) tested positive and 179 (89.5%) tested negative for malaria. All tests up to 9-months post-expiration were valid and consistent with reference mRDTs. All mRDTs 10- to 12-months post-expiration were invalid. These preliminary findings support further research into the use of expired mRDTs in resource limited settings.