Striking a nerve: Sensory neurons orchestrate ECM remodeling and immune exclusion in TNBC.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 41720072.
- Also identified by DOI 10.1016/j.cell.2026.01.020.
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Abstract
The tumor microenvironment drives cancer progression, yet neural contributions remain underexplored. Zhang et al. unravel a signaling circuit involving cancer cells, sensory neurons, and cancer-associated fibroblasts that promotes desmoplasia and excludes cytotoxic T cells, positioning the neuron-fibroblast axis as a therapeutic vulnerability and potential predictor of immunotherapy response.
Medical subject headings
- Sensory Receptor Cells
- Extracellular Matrix
- Triple Negative Breast Neoplasms