Interplay between dose, dose rate and endpoint in the tissue sparing effect of FLASH radiotherapy.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 41724390.
- Also identified by DOI 10.1016/j.radonc.2026.111452.
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Abstract
FLASH tissue sparing involves an interplay between dose, dose-rate and investigated endpoint. A risk zone map that divides the two-dimensional dose - dose-rate-space into different toxicity risk zones based on previous in-vivo data illustrates this interplay intuitively, including why FLASH sparing manifests at lower dose rates for severe compared to mild toxicity.
Medical subject headings
- Radiation Injuries
- Organ Sparing Treatments