COVID-19 Vaccines for 2025-2026 in Adults Who Are Not Pregnant or Immunocompromised: Rapid Practice Points From the American College of Physicians.

Qaseem, Amir; Obley, Adam J; Harrod, Curtis S; Wilt, Timothy J; Carroll, Kate; Humphrey, Linda L; Population Health and Medical Science Committee of the American College of Physicians; Haeme, Ray et al. · Ann Intern Med · 2026

review · Level V

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Abstract

The American College of Physicians (ACP) developed these rapid practice points addressing the effectiveness, comparative effectiveness, and harms of Omicron-adapted COVID-19 vaccines in adults (aged ≥18 years) who are not pregnant or immunocompromised. The ACP Population Health and Medical Science Committee developed the rapid practice points on the basis of a rapid review by the ACP Center for Evidence Reviews at Cochrane Austria and national disease surveillance data on the epidemiology and baseline risks for COVID-19. The following practice points apply to those who are not pregnant or immunocompromised. <i>Adults aged 65 years or older should receive an updated 2025-2026 mRNA-based COVID-19 vaccine.</i> <i>Adults aged 18 to 64 years at increased risk for severe COVID-19 should receive an updated 2025-2026 mRNA-based COVID-19 vaccine.</i> <i>Adults aged 18 to 64 years who are not at increased risk for severe COVID-19 may consider receiving an updated 2025-2026 mRNA-based COVID-19 vaccine.</i>

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