Highly selective and practical hydrogenation of functionalized (hetero)arenes.
basic_science · Level V
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- Record sourced from PubMed, PMID 41735254.
- Also identified by DOI 10.1038/s41467-026-68537-7 and PMC identifier 12936055.
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Abstract
Arenes, and particularly heteroarenes are integral structural components of a variety of chemicals and represent a privileged class of bioactive compounds found in pharmaceuticals, agrochemicals and vitamins. Diastereoselective hydrogenation of multi-substituted (hetero)arenes offers an efficient and industrially relevant approach to convert these compounds into valuable, diversified 3D building blocks for applications for example in drug innovation. We show that a rationally designed Pt catalyst permits the general diastereoselective hydrogenation of a broad range of multi-substituted and functionalized arenes and heteroarenes using mild conditions. The corresponding cyclic products are obtained with very high diastereoselectivity (d.r. value up to 99/1). The practical applicability of this catalysis is illustrated by the straightforward preparation of a novel plasticizer on kg-scale under solvent-free conditions.