Genetic network shaping Kenyon cell identity and function in <i>Drosophila</i> mushroom bodies.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 41758548.
- Also identified by DOI 10.7554/eLife.108173 and PMC identifier 12948353.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Revealing the molecular mechanisms underlying neuronal specification and acquisition of specific functions is key to understanding how the nervous system is constructed. In the <i>Drosophila</i> brain, <u>K</u>enyon <u>c</u>ells (KCs) are sequentially generated to assemble the backbone of the <u>m</u>ushroom <u>b</u>ody (MB). <u>B</u>road-complex, <u>t</u>ramtrack, and <u>b</u>ric-ȧ-brac <u>z</u>inc <u>f</u>inger <u>t</u>ranscription <u>f</u>actors (BTBzf TFs) specify early-born KCs, whereas the essential TFs for specifying late-born KCs remain unidentified. Here, we report that Pipsqueak domain-containing TF <i>Eip93F</i> promotes the identity of late-born KCs by reciprocally regulating gene expression in main KC types. Moreover, <i>Eip93F</i> not only regulates the expression of calcium channel <i>Ca-α1T</i> in late-born KCs to functionally control animal behavior, but it also forms a genetic network with <i>BTBzf TFs</i> to specify the identities of main KC types. Our study provides crucial information linking KC-type diversification to unique function acquisition in the adult MB.
Medical subject headings
- Mushroom Bodies
- Drosophila Proteins
- Gene Regulatory Networks
- Drosophila melanogaster
- Neurons