Scientific value and limitations of purified diets in animal research.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 41763197.
- Also identified by DOI 10.1016/j.cmet.2026.01.004.
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Abstract
Purified diets widely used in rodent studies lack bioactive compounds from whole foods that affect gut microbiota and host physiology; this may cause contradictory outcomes in some studies. Prioritizing biological relevance over compositional reproducibility and reassessing dietary models are crucial for improving scientific rigor.
Medical subject headings
- Diet
- Animal Experimentation
- Animal Feed