Development and trends in research on bibliometric analysis of bone marrow mesenchymal stem cells and fracture healing.
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- Record sourced from PubMed, PMID 41768853.
- Also identified by DOI 10.1016/j.jor.2026.01.017 and PMC identifier 12936760.
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Abstract
Fractures are among the most prevalent orthopedic disorders, and their healing represents a complex bone regeneration process. Delayed union, nonunion, and bone defects remain major clinical challenges. Bone marrow mesenchymal stem cells (BMSCs) play a pivotal role in fracture repair and bone regeneration; however, a comprehensive bibliometric evaluation of research trends and hotspots in this field is still lacking. This study aimed to systematically analyze the global research landscape concerning the role of BMSCs in fracture healing. A bibliometric analysis was conducted on publications related to BMSCs and fracture healing indexed in the Web of Science Core Collection from January 1997 to March 15, 2024. A total of 599 eligible articles were included. Bibliometric tools, including VOSviewer, CiteSpace, and Bibliometrix, were employed to analyze publication outputs, countries, institutions, authors, citation patterns, and keyword co-occurrence. The analysis revealed a steady growth in publications over time. China ranked first in terms of publication output, contributing 247 articles (35.19 % of the total). Professor Gang Li from the Chinese University of Hong Kong emerged as the most influential author, with 12 publications and an average of 39.75 citations per article. Zhejiang University was the most productive institution, publishing 20 articles. High-frequency keywords and clustering analysis indicated that current research hotspots focus on mesenchymal stem cells, osteogenic differentiation, gene expression, fracture healing, and bone repair. This bibliometric study provides a comprehensive overview of the research trends, key contributors, and emerging hotspots in the field of BMSC-mediated fracture healing. The findings highlight the dominant role of Chinese researchers and institutions and underscore osteogenic differentiation and regenerative mechanisms as core research directions. These insights may guide future basic and translational studies aimed at improving fracture repair strategies.