Why timing matters in MASLD: Late-day metabolic control.
Where this comes from
- Record sourced from PubMed, PMID 41780497.
- Also identified by DOI 10.1016/j.cmet.2026.02.006.
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Abstract
Metabolic dysfunction-associated steatotic liver disease (MASLD) is traditionally viewed as a static consequence of chronic caloric excess and insulin resistance. In the work previewed here, MASLD instead emerges as a disorder of time-of-day-dependent metabolic vulnerability, characterized by reduced insulin availability and worsening multisystem insulin resistance in the evening compared with the morning.
Medical subject headings
- Fatty Liver
- Circadian Rhythm