Regulatory T cells thrive in ammonia-rich tumors.
Where this comes from
- Record sourced from PubMed, PMID 41780498.
- Also identified by DOI 10.1016/j.cmet.2026.02.003.
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Abstract
In a recent issue of Cell, Gu et al. find that regulatory T (Treg) cells metabolize tumor-derived ammonia via the urea cycle and spermine synthesis, promoting immunosuppression through PPARγ-dependent oxidative phosphorylation. Inhibition of tumor glutamine metabolism reduces ammonia levels and overcomes Treg cell-mediated resistance to anti-PD-1 therapy.
Medical subject headings
- Ammonia
- T-Lymphocytes, Regulatory
- Neoplasms