The dual role of the pentose phosphate pathway in homeostasis and regeneration.
Where this comes from
- Record sourced from PubMed, PMID 41780499.
- Also identified by DOI 10.1016/j.cmet.2026.02.002.
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Abstract
In a recent issue of Cell, Song et al.<sup>1</sup> show that the pentose phosphate pathway (PPP) plays dual roles as a metabolic checkpoint. Spatial enrichment of PPP in peripheral nerves maintains mechanosensation homeostasis via NADPH-dependent redox balance, shifting to promote axon regeneration after injury by providing ribose-5-phosphate for RNA synthesis.
Medical subject headings
- Pentose Phosphate Pathway
- Homeostasis
- Nerve Regeneration