Central Precocious Puberty and Optic Pathway Glioma in Children with Neurofibromatosis 1: Associations with Tumor Location, Vision, and Treatment.
case_control · Level III
Where this comes from
- Record sourced from PubMed, PMID 41780670.
- Also identified by DOI 10.1016/j.jpeds.2026.115055 and PMC identifier 13288148.
- Licence recorded as CC BY-NC.
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Abstract
Neurofibromatosis 1-associated optic pathway gliomas (OPGs) may co-occur with central precocious puberty (CPP). Using large language model-based data analysis from 2 NF centers, we compared OPGs in children with NF1, with and without CPP. CPP was associated with hypothalamic involvement, poorer vision, and a higher likelihood of OPG treatment.
Medical subject headings
- Neurofibromatosis 1
- Optic Nerve Glioma
- Puberty, Precocious