Neuronal VIP shapes intestinal stem cell activity and mucosal immunity.
basic_science · Level V
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- Record sourced from PubMed, PMID 41795422.
- Also identified by DOI 10.1016/j.stem.2026.02.001.
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Abstract
Intestinal homeostasis and regeneration rely on intestinal stem cells (ISCs). Li et al.<sup>1</sup> identified neuronal vasoactive intestinal peptide (VIP) as a brake on ISCs through VIPR1 to limit regeneration. In Nature Immunology, Jakob et al. and Pirzgalska et al. further showed that VIP-VIPR1 signaling restrains secretory lineage expansion and balances immune responses.<sup>2</sup><sup>,</sup><sup>3</sup>.
Medical subject headings
- Vasoactive Intestinal Peptide
- Stem Cells
- Immunity, Mucosal
- Intestinal Mucosa
- Neurons
- Intestines