Tissues assemble! Rebuilding the human periportal liver in a dish.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 41795425.
- Also identified by DOI 10.1016/j.stem.2026.02.005.
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Abstract
In their recent Nature paper, Yuan et al. reconstruct patient-specific periportal architecture by assembling hepatocyte organoids with cholangiocytes and portal mesenchyme. Unlike previous attempts, these multicellular units recapitulate much of the cell-cell interaction found in the adult human liver, providing a new sophisticated platform to understand liver biology.
Medical subject headings
- Liver