CLIM-TIME links genetic cancer drivers to immune landscapes.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 41795439.
- Also identified by DOI 10.1016/j.cell.2026.01.014.
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Abstract
Immunotherapy resistance is associated with immune-privileged microenvironments, yet the interacting role of tumor-intrinsic genetics remains unclear. In this issue of Cell, Wang et al. introduce CLIM-TIME, a spatially resolved in vivo CRISPR screening platform linking loss of tumor suppressor genes to distinct metastatic immune architectures and divergent responses to immunotherapy.
Medical subject headings
- Neoplasms