Non-canonical muscle stem cells and other lessons from regenerative vertebrates.
basic_science · Level V
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- Record sourced from PubMed, PMID 41803172.
- Also identified by DOI 10.1038/s41536-026-00468-9.
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Abstract
In this perspective, we explore the developmental mechanisms of muscle stem cells in multiple non-mammalian vertebrate species, and we compare these phenomena to those in mammals. Particularly, we discuss two recently described populations of noncanonical muscle progenitors in regenerative vertebrates: one in zebrafish and one in axolotl. We discuss the capabilities of these two populations during muscle development and regeneration, including the implications for muscle repair in mammals.