Gene-environment equivalence: The fundamental principle of Mendelian randomization.

Davey Smith, George; Hemani, Gibran; Ebrahim, Shah · PLoS Med · 2026

review · Level V

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Abstract

The explosion of Mendelian Randomization (MR) submissions of dubious quality to journals globally is well recognized. Contributing to this deluge of publications may be the poor understanding among practitioners, reviewers, and editors of gene-environment equivalence, the fundamental principle of MR.

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