Seeing through collagen: integrative pro-regenerative corneal implants for clearer future.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 41832165.
- Also identified by DOI 10.1038/s41536-026-00471-0.
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Abstract
Collagen-based artificial corneas are a promising regenerative alternative to scarce donor tissue. However, their clinical success is limited by mechanical weakness, enzymatic degradation, and poor bio-integration. This review provides a comprehensive analysis of the current state and the future strategies to optimize collagen for making pro-regenerative corneal implants, enhancing the performance, functionality, and clinical viability of the collagen-based artificial cornea as a substitute for donor tissue.