Skin-Inspired MXene@PEDOT:PSS/Bacterial Cellulose Janus Film for Enhanced Skin Bioelectronics and Accelerated Wound Healing.

Abstract

Recent advancements in skin bioelectronics have significantly transformed personalized daily healthcare monitoring and wound management. Consequently, the development of advanced smart wound-dressing systems, such as bioelectronics-integrated wound dressings, has the potential to address numerous clinical challenges associated with effective wound management. Herein, we introduce a versatile Janus film composed of MXene@PEDOT:PSS and bacterial cellulose (designated as MPP/BC), developed as an innovative and adaptable bioelectronics-integrated wound dressing. This material is designed to enhance skin bioelectronics for health monitoring while facilitating accelerated wound healing. The resulting MPP/BC Janus film exhibits remarkable flexibility, high conductivity, photothermal sterilization capabilities, and excellent biocompatibility. These essential characteristics render it suitable for integration into a versatile epidermal sensor capable of real-time monitoring of various human physiological signals. Furthermore, this MPP/BC Janus film-based wound dressing demonstrates significant potential in enhancing therapeutic efficacy to promote wound healing by facilitating epithelial regeneration and increasing collagen deposition. Consequently, this study introduces a promising strategy for developing advanced smart wound-dressing systems aimed at accelerating and optimizing the wound healing process. This bioelectronics-integrated wound dressing holds significant potential for applications in skin bioelectronics, particularly in continuous health monitoring and intelligent wound management.