Unlocking the reducing power of metal nitrides by mechanochemical hydrodefluorination of fluorinated compounds.
basic_science · Level V
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- Record sourced from PubMed, PMID 41851128.
- Also identified by DOI 10.1038/s41467-026-70813-5.
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Abstract
The carbon-fluorine (C-F) bond, present in both aromatic C(sp<sup>2</sup>)-F and aliphatic C(sp<sup>3</sup>)-F moieties, possesses an exceptionally high bond energy. This inherent stability renders C-F bond activation highly challenging. In this work, we address this challenge and reclaim valuable hydrocarbons from fluorinated compounds, including aryl fluorides, alkyl fluorides, and perfluoroalkyl substances, by developing a mechanochemical hydrodefluorination strategy. This approach exploits metal nitrides, particularly magnesium nitride, as reductants, contrasting with previous perception of metal nitrides as merely ammonia surrogates in organic reactions. Remarkably, this mechanochemical protocol achieves the degradation of even persistent polytetrafluoroethylene (Teflon®), a prototypical "forever chemical".