Advancing diagnostic equity through artificial intelligence chest radiograph screening for osteoporosis in Asian populations.
cross_sectional · Level IV
Where this comes from
- Record sourced from PubMed, PMID 41857300.
- Also identified by DOI 10.1038/s41746-026-02484-x.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Early identification of abnormal bone mineral density (BMD) through opportunistic screening is critical for preventing osteoporotic fractures. We validated an AI model in 2384 asymptomatic adults (57.7% female; mean age 43.6 years) undergoing health examinations in Taiwan. Using DXA as the reference, the model identified 255 suspected abnormal BMD cases, with 94 (3.9%) DXA-confirmed positive. Population-level performance was robust, yielding an AUC of 0.95 (95% CI 0.93-0.99) and sensitivity of 79.7% (95% CI 71.3-86.5%). Although BMI distributions paralleled East Asian regional trends, intersectional subgroup analyses remain exploratory due to small event counts. Decision curve analysis indicated superior net benefit for AI-based referral over "refer all" or "refer none" strategies, particularly for women with normal BMI (18.5-23 kg/m²). This AI tool offers precise triage for Asian health examination populations, though further validation in multi-center cohorts is required to confirm broad generalizability.