Innovating global regulatory frameworks for generative AI in medical devices is an urgent priority.

Ong, Jasmine Chiat Ling; Ning, Yilin; Liu, Mingxuan; Ma, Yian; Zhao, Liang; Singh, Kuldev; Chang, Robert T; Vogel, Silke et al. · NPJ Digit Med · 2026

expert_opinion · Level V

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Abstract

The integration of generative AI (GenAI) and large language models (LLMs) in healthcare presents both unprecedented opportunities and challenges, necessitating innovative regulatory approaches. In this perspective, we discuss the risks of GenAI and LLM-based medical devices, the limitations of current medical device regulation frameworks when applied to GenAI or LLMs, and advocate for global collaboration in regulatory science research through engaging multidisciplinary expertise and focusing on the needs of diverse populations.