Nonequilibrium fluctuation-response relations for state observables.

Abstract

Time-integrated state observables, which quantify the fraction of time spent by the system in a specific pool of states, are important in many fields, such as chemical sensing or the theory of fluorescence spectroscopy. We derive exact identities, called fluctuation-response relations, that connect the fluctuations of such observables to their response to external perturbations in nonequilibrium steady state of Markov jump processes. Using these results, we derive an upper bound on fluctuations of state observables, as well as some lower bounds. We further demonstrate how our identities provide a deeper understanding of the mechanistic origin of fluctuations and reveal their properties dependent only on system topology, which may be relevant for model inference using measured data.