Severity-dependent atrial remodeling and atrial fibrillation vulnerability in a clinically relevant aortic regurgitation mouse model.

Lakin, Robert; Liu, Xueyan; Sherrard, Dana; Parikh, Mihir; Debi, Ryan; Polidovitch, Nazari; Duncan, Markus J; Wu, Jian et al. · JCI Insight · 2026

basic_science · Level V

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Abstract

Severity of aortic regurgitation correlates with atrial stretch and fibrillation. Uncovering stretch-mediated atrial remodeling prior to ventricular pathology will help define optimal timing of interventions.

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