Primary malignant aneurysmal bone cyst of the metatarsal with PAFAH1B1::USP6 fusion: expanding the clinicopathologic spectrum of malignant USP6 translocated neoplasms.
case_report · Level V
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- Record sourced from PubMed, PMID 41880003.
- Also identified by DOI 10.1007/s00256-026-05167-6.
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Abstract
Malignant aneurysmal bone cyst is not a well described concept. We present a case of a morphologically malignant bone tumour, interpreted as a malignant aneurysmal bone cyst with areas of characteristic morphology, a myofibroblastic phenotype, and a proven PAFAH1B1:USP6 fusion. The radiologic, morphologic and molecular features of this unusual case are discussed, along with the spectrum of atypical/malignant USP6 translocated tumours.
Anatomy
- foot