Clinical Reasoning: A 41-Year-Old Man Presenting With Right Foot Tingling.

Lu, Vivien; Pons, Carmen; Pytel, Peter; Horowitz, Peleg; Lara, Carlos; Priyadarshini, Shubadra; Soliven, Betty; Cipriani, Veronica P et al. · Neurology · 2026

case_report · Level V

Where this comes from

Abstract

The diagnostic evaluation of progressive, multifocal sensory neuropathy can be challenging and prone to misdirection without a broad differential diagnosis and a careful clinical history. We present a 41-year-old healthy man with insidious onset of right foot paresthesia, which gradually extended to his left foot and right hand over several months. This case illustrates a systematic clinical reasoning approach to multifocal neuropathy, culminating in the unexpected diagnosis of a treatable cause for neuropathy. The case underscores the importance of maintaining diagnostic openness to rare but treatable causes in the evaluation of atypical neuropathy presentations.

Medical subject headings

Anatomy