Screening and regulation of nanozyme activity via liquid metals coined electron rearrangement and phase engineering.
basic_science · Level V
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- Record sourced from PubMed, PMID 41888172.
- Also identified by DOI 10.1038/s41467-026-70795-4.
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Abstract
Liquid metals (LMs) have been used for design of advanced materials by leveraging their unique liquid and electronic properties. Here, we design a series of liquid metal-buffered amorphous molybdenum sulfide nanozymes with different gallium indium ratios, in which Ga<sub>75.5</sub>In<sub>24.5</sub> MoS<sub>X</sub> nanozymes exhibit the enzyme-like activity, superior to the crystalline MoS<sub>2</sub>. This has been verified and assigned to the roles of liquid metal: (i) serving as the building template, (ii) phase engineering with catalytic active sites, (iii) electron-rich microenvironment for improving catalytic activity. Besides, the amorphous Ga<sub>75.5</sub>In<sub>24.5</sub> MoS<sub>X</sub> nanozyme possesses oxidase (OXD)-like and nicotinamide adenine dinucleotide oxidase (NOX)-like activity to achieve multiple-enzyme-like cascade catalytic reactions, disrupting intratumoral redox and metabolism homeostasis. As the example of leveraging liquid metal as a well-designed platform to screen high-performance nanozyme with excellent therapeutic effects, this work highlights the roles of tailored electronic structure and phase engineering for regulation of catalytic activity of nanozymes and may also broaden the application of liquid metal in catalysis and biomedical field.