Photoinduced Mn catalysis for efficient platform for C-heteroatom bond coupling of aryl halides.
basic_science · Level V
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- Record sourced from PubMed, PMID 41896220.
- Also identified by DOI 10.1038/s41467-026-70925-y.
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Abstract
Photoinduced transition metal catalysis offers innovative strategies for fostering novel chemical reactions and improving established ones. In this work, we present a highly efficient, photoinduced Mn(II)-bipyridine catalyzed C-N, C-O and C-S coupling reaction between aryl halides-particularly less reactive aryl chlorides-and nucleophiles containing nitrogen, oxygen, and sulfur. This protocol does not need an external photocatalyst, as the single Mn(II)-bipyridine complex simultaneously serves as both the light-harvester and the metal catalyst. This method exhibits excellent substrate scope, covering eight different nitrogen sources for C-N coupling, as well as C-O coupling with alcohols, C-S coupling with thiophenols, encompassing more than 150 examples, with yields reaching up to 94%. Mechanistic studies suggest that this reaction may be initiated and sustained by the Mn(I) species through the photoinduced homolysis of the catalyst precursor bipyridine-Mn(II)(OAc)<sub>2</sub>, likely proceeding via a Mn(I)/Mn(III) catalytic cycle.