Diffuse Hepatic, Splenic, and Osseous Activity Due to Multiple Myeloma.

Zhao, Xiaoyi; Liang, Huan; Zhao, Guoxing; Wei, Lingge; Xie, Peng · Clin Nucl Med · 2026

case_report · Level V

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Abstract

Patients with multiple myeloma (MM) presenting diffuse extramedullary infiltration of the liver and spleen are extremely rare. Here we present the 18 F-FDG PET/CT findings of a 53-year-old man who complained of eyelids swelling for more than 4 months. The 18 F-FDG PET/CT demonstrated diffuse intense uptake in the bone, liver, and spleen. Finally, the diagnosis of MM with hepatic and splenic involvement was confirmed.

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