In morphea, cytotoxic resident memory T cells induce chronic, immunogenic endothelial cell injury via necroptosis.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 41926212.
- Also identified by DOI 10.1172/jci.insight.201949.
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Abstract
Chronic skin fibrosis in morphea results from resident memory T cells that kill endothelial cells through inflammatory cell death and sustain injury and scarring.
Medical subject headings
- Endothelial Cells
- Scleroderma, Localized
- Necroptosis
- T-Lymphocytes, Cytotoxic