Less is more: Reducing zinc to boost stem cell-derived islet function and survival.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 41932319.
- Also identified by DOI 10.1016/j.stem.2026.03.010.
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Abstract
Zinc is required for insulin packaging into secretory granules, yet reduced zinc transporter activity paradoxically enhances beta cell function. In this issue, Wang et al.<sup>1</sup> show that pharmacologic inhibition of zinc transport in stem cell-derived islets activates AMPK signaling and improves maturation, hypoxia resistance, VEGFA expression, and graft performance.
Medical subject headings
- Zinc
- Islets of Langerhans
- Stem Cells