Turning drivers into regulators: In vivo CAR reprogramming of Tfh cells.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 41932320.
- Also identified by DOI 10.1016/j.stem.2026.03.011.
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Abstract
Autoimmune hepatitis (AIH) is a progressive, life-threatening liver disease that remains treated largely with broad immunosuppression. In this issue of Cell Stem Cell, Jing and colleagues reprogram follicular helper T (Tfh) cells in vivo into antigen-specific FOXP3⁺ CAR-Tfh cells to restore immune tolerance by rewiring core drivers of autoimmunity.
Medical subject headings
- T Follicular Helper Cells
- Cellular Reprogramming
- T-Lymphocytes, Helper-Inducer
- Receptors, Chimeric Antigen