Endogenous aldehydes: A driver of clonal hematopoiesis from within?
editorial · Level V
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- Record sourced from PubMed, PMID 41932322.
- Also identified by DOI 10.1016/j.stem.2026.03.009.
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Abstract
Detoxification of endogenous aldehydes is critical for preserving genomic integrity in hematopoietic stem cells. In this issue, Kamimae-Lanning et al.<sup>1</sup> show that excess formaldehyde can drive clonal hematopoiesis through attrition of blood-forming progenitors, accelerating neutral drift in the absence of known genetic drivers of positive selection.
Medical subject headings
- Clonal Hematopoiesis
- Aldehydes
- Hematopoietic Stem Cells
- Hematopoiesis