High-intensity respiratory muscle training improves maximal respiratory pressures, breathing endurance, dyspnoea and exercise capacity in people with Parkinson's disease: a randomised trial.
rct · Level II
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- Record sourced from PubMed, PMID 41933952.
- Also identified by DOI 10.1016/j.jphys.2026.03.006.
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Abstract
What is the effect of home-based, high-intensity, combined inspiratory and expiratory muscle training on maximal respiratory pressures, inspiratory muscle endurance, peak cough flow, dyspnoea, fatigue, exercise capacity and quality of life in people with Parkinson's disease? A randomised controlled trial with concealed allocation, intention-to-treat analysis and blinding of participants, assessors and statisticians. People with Parkinson's disease. The experimental group received high-intensity combined inspiratory and expiratory muscle training at 60% of maximal inspiratory pressure (MIP) and 60% of maximal expiratory pressure (MEP). The control group received sham training using the same protocol, but without any resistive load. Both groups trained for 20 minutes, twice per day, 7 days/week for 8 weeks. The primary outcome was respiratory muscle strength (MIP and MEP). Secondary outcomes included inspiratory muscle endurance, peak cough flow, dyspnoea (0-to-4 Medical Research Council scale, where lower scores are better), fatigue (1-to-7 Fatigue Severity, where lower scores are better), exercise capacity (6-minute walk test) and quality of life (0-to-100 Parkinson's Disease Questionnaire-39, where lower scores are better). All outcomes were measured at 0, 8 and 12 weeks. Thirty-four participants were included. Compared with control, the experimental group had better MIP (MD 20 cmH<sub>2</sub>O, 95% CI 10 to 30), MEP (MD 24 cmH<sub>2</sub>O, 95% CI 10 to 39) and inspiratory muscle endurance (MD 1.2 minutes, 95%CI 0.4 to 2.0). The benefits in MIP and inspiratory muscle endurance were maintained at follow-up. Benefits also occurred in dyspnoea (MD -0.71, 95% CI -1.30 to -0.12) and exercise capacity (MD 24.9 m, 95% CI 0.2 to 49.7); however, the confidence intervals spanned worthwhile and trivial effects, indicating uncertainty about whether those effects are clinically worthwhile. High-intensity combined inspiratory and expiratory muscle training improved respiratory muscle strength, inspiratory muscle endurance, dyspnoea and exercise capacity in people with Parkinson's disease. NCT05608941.