Multimodal Approach to a Photopenic Defect on FDOPA PET/MR in a Case of Glioblastoma and its Progression.
case_report · Level V
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- Record sourced from PubMed, PMID 41945366.
- Also identified by DOI 10.1097/RLU.0000000000006434.
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Abstract
We report the case of a 52-year-old man who presented with a diffuse, nonenhancig right frontotemporal lesion on MRI, without a solid component. Neither FDG nor FDOPA PET/MR was able to identify a hypermetabolic focus to guide the biopsy, but photopenic defect. Stereotactic biopsy performed at the temporal region revealed a IDH wild-type glioblastoma with a Ki-67 index below 1%. Seven months after biopsy, aggressive tumor growth was observed around the biopsy tract, with a solid enhancing mass and very high FDOPA and FDG uptake, typical for a glioblastoma. The patient died 28 months after diagnosis.
Medical subject headings
- Glioblastoma
- Multimodal Imaging
- Positron-Emission Tomography
- Magnetic Resonance Imaging
- Dihydroxyphenylalanine
- Disease Progression
- Brain Neoplasms
- Light