Extranodal Natural Killer/T-Cell Lymphoma Mimicking Chronic Mucormycosis.

Yun, Jun; Lin, Matthew E; Madrigal, Josef; Tyagi, Rakshit; Ni, Garrett; Chia, Jennifer J; Kang, Robert · Laryngoscope · 2026

case_report · Level V

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Abstract

We describe a rare case of a 34-year-old woman who presented with progressive, destructive midline facial lesions initially concerning for chronic rhinofacial mucormycosis. However, subsequent tissue biopsy and pathologic evaluation established the diagnosis of extranodal NK/T-cell lymphoma. The patient demonstrated rapid disease progression despite prompt initiation of asparaginase-based chemotherapy, highlighting the diagnostic challenges and aggressive course of this malignancy that may resemble invasive fungal infection.