Hyperreflective Foci in the Inner Nuclear Layer: Proof-of-Concept for an Optical Coherence Tomography Derived Microglia-Related Marker in Multiple Sclerosis.
Where this comes from
- Record sourced from PubMed, PMID 41947446.
- Also identified by DOI 10.1002/ana.78215 and PMC identifier 13206537.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
The role of microglia has emerged as a critical driver of disease progression in multiple sclerosis (MS), but we lack broadly applicable monitoring tools. Here, we investigated whether hyperreflective foci (HRF), as detected by optical coherence tomography (OCT) within the inner nuclear layer (INL) of the retina, can be used as a marker for microglial pathology. We demonstrate that HRF counts are increased in persons with relapsing and progressive MS and correlate with global white and gray matter, as well as deep gray matter [<sup>18</sup>F]GE-180 uptake. [Color figure can be viewed at www.annalsofneurology.org] ANN NEUROL 2026;99:1480-1485.
Medical subject headings
- Tomography, Optical Coherence
- Microglia
- Multiple Sclerosis
- Multiple Sclerosis, Relapsing-Remitting
- Retina