Widespread Skeletal Metastases in Medullary Thyroid Carcinoma: Diagnostic Superiority of 68 Ga-FAPI PET/CT Over Somatostatin Receptor-Targeted Imaging.
case_report · Level V
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- Record sourced from PubMed, PMID 41950235.
- Also identified by DOI 10.1097/RLU.0000000000006450.
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Abstract
A 78-year-old woman with medullary thyroid carcinoma (MTC) demonstrated persistently elevated serum calcitonin despite prior surgery and radiotherapy. 99m Tc-octreotide imaging failed to detect skeletal metastases, while 68 Ga-FAPI PET/CT revealed extensive skeletal involvement. Biochemical markers were disproportionately low relative to disease burden, consistent with a low-secretory MTC. This case highlights the limitations of SSTR-targeted imaging in MTC and underscores the diagnostic superiority of FAP-targeted imaging.
Medical subject headings
- Positron Emission Tomography Computed Tomography
- Thyroid Neoplasms
- Receptors, Somatostatin
- Carcinoma, Neuroendocrine
- Bone Neoplasms
- Serine Endopeptidases
- Membrane Proteins