Extracranial Metastases From FET-CREB Fusion-positive Intracranial Mesenchymal Tumor on FDG PET/CT.

Wang, Jiawen; He, Sihan; Ran, Bingbing; Dong, Aisheng; Zhao, Hongguang · Clin Nucl Med · 2026

case_report · Level V

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Abstract

FET-CREB fusion-positive intracranial mesenchymal tumor is a newly recognized provisional tumor type. Usefulness of FDG PET/CT in the management of this tumor is rarely reported. We describe FDG PET/CT findings in a case of FET-CREB fusion-positive intracranial mesenchymal tumor with metachronous extracranial metastases to the mediastinum, mesentery, and left Leg. The metastatic tumors showed mild to moderate FDG uptake. This case indicates that FET-CREB fusion-positive intracranial mesenchymal tumors can develop extracranial metastasis, and FDG PET/CT may be useful for detecting extracranial metastasis of this rare tumor.

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