Ultrafine-grained biodegradable zinc alloys with superior mechanical performance and osteo-angiogenic activity for guided bone regeneration membranes.
biomechanical · Level V
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- Record sourced from PubMed, PMID 41950576.
- Also identified by DOI 10.1016/j.jmbbm.2026.107424.
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Abstract
Biodegradable zinc (Zn) alloys are promising candidates for guided bone regeneration (GBR) membranes because they combine adequate mechanical support with controllable biodegradation rate. Here, three ultrafine-grained (UFG) Zn alloys were fabricated by room-temperature rolling and systematically evaluated for microstructures, mechanical properties, corrosion behavior, and in vitro biological responses. Electron backscatter diffraction and transmission electron microscopy confirmed UFG microstructures in all alloys, with average grain sizes <1 μm. Depending on the alloying elements, nanoscale precipitates (MgZn<sub>2</sub>, MnZn<sub>13</sub>, or CuZn<sub>5</sub>) were formed. Mechanical testing showed that Zn-0.1 Mg achieved the highest tensile strength (313 MPa), whereas Zn-0.4Mn and Zn-0.5Cu exhibited greater ductility, with elongations of 135% and 198%, respectively. Corrosion assessments indicated that Zn-0.4Mn had the lowest degradation rate, while Zn-0.1 Mg showed a severely localized corrosion and the highest degradation rate. All alloys demonstrated good cytocompatibility in vitro. Zn-0.1 Mg further enhanced angiogenic potential and osteogenic differentiation. Collectively, these results clarify how alloy chemistry and UFG microstructures jointly regulate the mechanical performance, corrosion, and biological performance of Zn alloys, offering design guidance for next-generation biodegradable GBR membrane materials.