Vitamin C slows primate aging by targeting iron-driven lipid peroxidation.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 41950897.
- Also identified by DOI 10.1016/j.cmet.2026.02.011.
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Abstract
Aging has long been associated with oxidative stress, yet its underlying metabolic drivers remain unclear. Liu et al. identify a conserved, iron-driven lipid peroxidation of primate aging mediated by ACSL4 and demonstrate that vitamin C directly suppresses this process, offering a translatable strategy to mitigate age-associated functional decline.
Medical subject headings
- Ascorbic Acid
- Aging
- Lipid Peroxidation
- Iron