One-step construction of robust protocells and prototissues in water.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 41951631.
- Also identified by DOI 10.1038/s41467-026-71650-2.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Bottom-up assembly of protocell building blocks into self-supporting, macroscopic, and robust prototissues that are stable in water and exhibit biomimetic behaviors remains a fundamental challenge. Here, we present a gas-liquid microfluidics-assisted diffusion-inhibited complexation strategy that enables low-cost, high-throughput fabrication of protocells and precise, large-scale (>10 cm) 3D construction of prototissues. The resulting prototissues display good mechanical integrity in both water and air and resist disintegration under external perturbations. By modulating the surrounding matrix or integrating bioactive components into the prototissue framework, programmable deformation/motion can be achieved through chemo-mechanical transduction. This strategy provides a platform for modeling the intricate behaviors of living systems and may facilitate applications in synthetic biology and bioengineering.