Outcomes Following en Bloc Resection of Olfactory Neuroblastoma.

Abstract

Olfactory neuroblastoma (ONB) is a rare malignant tumor originating from the nasal olfactory sensory epithelium. It accounts for 3%-5% of all sinonasal malignancies. We evaluated patients with ONB who underwent en bloc resection using an endoscopic endonasal transcribriform approach. This study included 65 patients. The median follow-up period was 30.6 months. The 2- and 5-year overall survival (OS) rates were both 96.7%, the 2- and 5-year disease-specific survival (DSS) rates were both 98.3%, and the 2- and 5-year disease-free survival (DFS) rates were 81.7% and 59.1%, respectively. OS and DFS of en bloc resection were comparable to those reported in previous studies, with minimal operation-related complications. Recurrence can occur even in patients with low Kadish and Hyams grades, making it unclear which patients would benefit most from postoperative radiation therapy.