Primary High-grade Urothelial Carcinoma of the Prostate With Negative 18F-PSMA PET/CT Imaging.
case_report · Level V
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- Record sourced from PubMed, PMID 41955233.
- Also identified by DOI 10.1097/RLU.0000000000006468.
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Abstract
This case report describes an 81-year-old man with primary high-grade urothelial carcinoma of the prostate, which presented with a negative 18 F-PSMA PET/CT. Contrast-enhanced prostate MRI initially suggested a malignant lesion; however, 18 F-PSMA PET/CT revealed no significant tracer uptake. Postoperative immunohistochemical analysis demonstrated positivity for urothelial markers GATA3 and CK7, while prostate-specific markers PSA and AR were negative, confirming the diagnosis of primary high-grade urothelial carcinoma of the prostate. This case indicates that a negative PSMA PET/CT scan may serve as an important diagnostic clue in distinguishing non-adenocarcinomatous prostate malignancies.
Medical subject headings
- Prostatic Intraepithelial Neoplasia
- Prostatic Neoplasms
- Positron Emission Tomography Computed Tomography