Letter to the editor Re: Integrated metabolomics and proteomics to screen early diagnostic biomarkers of venous thromboembolism following severe trauma.
editorial · Level V
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- Record sourced from PubMed, PMID 41956843.
- Also identified by DOI 10.1016/j.injury.2026.113245.
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Abstract
This letter critically appraises the recent multi-omics study by Gou et al. proposing early biomarkers for venous thromboembolism after severe trauma, highlighting concerns regarding residual confounding, physiological instability at sampling, and limited external validity. While innovative and hypothesis-generating, the findings require prospective validation with rigorous adjustment for injury severity and resuscitation factors before clinical translation.